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Scar Team

24 hours ago

Dr Ardeshir Bayat made some interesting observations about keloids at The Scar II Conference. There has long been a parallel between these pronounced proliferative scars and cancer. Although keloids are not dangerous and do not spread to distant sites, they can invade locally and are resistant to many forms of treatment. Dr Bayat focused on the science of how the environment in a keloid mirrors that of a cancer. Both have a relative lack of oxygen. Keloid fibroblasts grown outside of the body on a culture plate spread and grow in a manner that is not dissimilar to cancer cell lines. Moreover, many keloid cells have increased levels of chemicals internally which mirror signalling pathways that go wrong in cancer. These include those related to TGFbeta, notch and mTOR. ...